Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture.However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability.To overcome this, we engineered mammalian cells to rapid